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Assay Detail

CHEMBL3280959

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of malate dehydrogenase (unknown origin) by spectrophotometry
26
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Malate dehydrogenase, mitochondrial (CHEMBL5917)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration.
Shah KJ, Coats EA.
J Med Chem (1977) 20 : 1001 -1006
PubMed 894670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.90 5.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL157654 2 5.32
CHEMBL157710 2 4.50
CHEMBL344461 2 -
CHEMBL345688 2 -
CHEMBL141025 2 -
CHEMBL138298 2 -
CHEMBL139244 2 -
CHEMBL160456 2 -
CHEMBL139078 2 -
CHEMBL343799 2 -
CHEMBL138027 2 -
CHEMBL139402 2 -
CHEMBL1161215 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL157654 IC50 = 4786.3 nM 5.32
CHEMBL157654 IC50 = 5000.0 nM 5.30
CHEMBL157710 IC50 = 32000.0 nM 4.50
CHEMBL157710 IC50 = 32359.37 nM 4.49
CHEMBL345688 IC50 = 10550000.0 nM -
CHEMBL141025 IC50 = 910000.0 nM -
CHEMBL138298 IC50 = 480000.0 nM -
CHEMBL139244 IC50 = 1890000.0 nM -
CHEMBL160456 IC50 = 740000.0 nM -
CHEMBL139078 IC50 = 1070000.0 nM -
CHEMBL343799 IC50 = 660000.0 nM -
CHEMBL138027 IC50 = 490000.0 nM -
CHEMBL139402 IC50 = 950000.0 nM -
CHEMBL1161215 IC50 = 2140000.0 nM -
CHEMBL344461 IC50 = 3620000.0 nM -
CHEMBL345688 IC50 = 10471285.48 nM -
CHEMBL141025 IC50 = 912010.84 nM -
CHEMBL138298 IC50 = 478630.09 nM -
CHEMBL139244 IC50 = 1905460.72 nM -
CHEMBL160456 IC50 = 741310.24 nM -
CHEMBL139078 IC50 = 1071519.31 nM -
CHEMBL343799 IC50 = 660693.45 nM -
CHEMBL138027 IC50 = 489778.82 nM -
CHEMBL139402 IC50 = 954992.59 nM -
CHEMBL1161215 IC50 = 2137962.09 nM -
CHEMBL344461 IC50 = 3630780.55 nM -