Assay Detail
Binding
CHEMBL3281223
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Antagonist activity at angiotensin AT2 receptor in rabbit aortic strips assessed as inhibition of angiotensin 2- myotropic mediated response
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of angiotensin II antagonists containing N- and O-methylated and other amino acid residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.30 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 9.17 |
| CHEMBL2371400 | — | — | 1 | 8.79 |
| CHEMBL3248823 | — | — | 1 | 8.76 |
| CHEMBL3276829 | — | — | 1 | 8.74 |
| CHEMBL3276833 | — | — | 1 | 8.63 |
| CHEMBL3276834 | — | — | 1 | 8.08 |
| CHEMBL3276832 | — | — | 1 | 7.89 |
| CHEMBL3276831 | — | — | 1 | 7.85 |
| CHEMBL385919 | — | — | 1 | 7.64 |
| CHEMBL3276830 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 0.6761 | nM | 9.17 |
| CHEMBL2371400 | — | Kd | = | 1.622 | nM | 8.79 |
| CHEMBL3248823 | — | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL3276829 | — | Kd | = | 1.82 | nM | 8.74 |
| CHEMBL3276833 | — | Kd | = | 2.344 | nM | 8.63 |
| CHEMBL3276834 | — | Kd | = | 8.318 | nM | 8.08 |
| CHEMBL3276832 | — | Kd | = | 12.88 | nM | 7.89 |
| CHEMBL3276831 | — | Kd | = | 14.13 | nM | 7.85 |
| CHEMBL385919 | — | Kd | = | 22.91 | nM | 7.64 |
| CHEMBL3276830 | — | Kd | = | 36.31 | nM | 7.44 |