Assay Detail
Binding
CHEMBL3281224
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Antagonist activity at angiotensin AT2 receptor in isolated cat adrenal medulla
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Felis catus |
| Tissue | Adrenal medulla |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of angiotensin II antagonists containing N- and O-methylated and other amino acid residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.66 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 9.50 |
| CHEMBL3276834 | — | — | 1 | 9.33 |
| CHEMBL385919 | — | — | 1 | 9.31 |
| CHEMBL3276830 | — | — | 1 | 9.16 |
| CHEMBL3276833 | — | — | 1 | 9.16 |
| CHEMBL2371400 | — | — | 1 | 9.00 |
| CHEMBL3276829 | — | — | 1 | 8.16 |
| CHEMBL3276831 | — | — | 1 | 8.00 |
| CHEMBL3276832 | — | — | 1 | 8.00 |
| CHEMBL3248823 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL3276834 | — | Kd | = | 0.4677 | nM | 9.33 |
| CHEMBL385919 | — | Kd | = | 0.4898 | nM | 9.31 |
| CHEMBL3276830 | — | Kd | = | 0.6918 | nM | 9.16 |
| CHEMBL3276833 | — | Kd | = | 0.6918 | nM | 9.16 |
| CHEMBL2371400 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL3276829 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL3276831 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL3276832 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL3248823 | — | Kd | = | 100.0 | nM | 7.00 |