Assay Detail
Binding
CHEMBL3285488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase (peak-1) isolated from pig coronary artery assessed as inhibition of cAMP hydrolysis using 1 uM cAMP substrate in presence of 3% Me2SO
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of separated forms of phosphodiesterases from pig coronary arteries by uracils and by 7-substituted derivatives of 1-methyl-3-isobutylxanthine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.01 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3272816 | — | — | 1 | 5.89 |
| CHEMBL3272817 | — | — | 1 | 5.64 |
| CHEMBL3272811 | — | — | 1 | 5.57 |
| CHEMBL26606 | — | — | 1 | 5.44 |
| CHEMBL3272818 | — | — | 1 | 5.43 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.41 |
| CHEMBL3272808 | — | — | 1 | 5.26 |
| CHEMBL3272810 | — | — | 1 | 4.77 |
| CHEMBL3272809 | — | — | 1 | 4.72 |
| CHEMBL3272815 | — | — | 1 | 4.72 |
| CHEMBL3272813 | — | — | 1 | 4.57 |
| CHEMBL24444 | — | — | 1 | 4.55 |
| CHEMBL3272812 | — | — | 1 | 4.46 |
| CHEMBL3272814 | — | — | 1 | 4.39 |
| CHEMBL25096 | — | — | 1 | 4.26 |
| CHEMBL3272819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3272816 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3272817 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3272811 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL26606 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3272818 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3272808 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3272810 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3272809 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3272815 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3272813 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL24444 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3272812 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3272814 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL25096 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3272819 | — | IC50 | = | 105000.0 | nM | - |