Assay Detail
Binding
CHEMBL3285489
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Inhibition of phosphodiesterase (peak-2) isolated from pig coronary artery assessed as inhibition of cAMP hydrolysis using 1 uM cAMP substrate in presence of 3% Me2SO
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of separated forms of phosphodiesterases from pig coronary arteries by uracils and by 7-substituted derivatives of 1-methyl-3-isobutylxanthine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.53 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3272808 | — | — | 1 | 5.17 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 4.82 |
| CHEMBL3272818 | — | — | 1 | 4.70 |
| CHEMBL3272811 | — | — | 1 | 4.55 |
| CHEMBL3272817 | — | — | 1 | 4.37 |
| CHEMBL3272816 | — | — | 1 | 4.32 |
| CHEMBL24444 | — | — | 1 | 4.19 |
| CHEMBL3272815 | — | — | 1 | 4.12 |
| CHEMBL25096 | — | — | 1 | - |
| CHEMBL3272809 | — | — | 1 | - |
| CHEMBL3272810 | — | — | 1 | - |
| CHEMBL26606 | — | — | 1 | - |
| CHEMBL3272812 | — | — | 1 | - |
| CHEMBL3272813 | — | — | 1 | - |
| CHEMBL3272814 | — | — | 1 | - |
| CHEMBL3272819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3272808 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3272818 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3272811 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3272817 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3272816 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL24444 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3272815 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL25096 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL3272809 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3272810 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26606 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL3272812 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3272813 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3272814 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL3272819 | — | IC50 | > | 300000.0 | nM | - |