Assay Detail
Functional
CHEMBL3291702
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Anticancer activity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.42 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.90 |
| CHEMBL453981 | GANODERIC ACID F | — | 1 | 4.71 |
| CHEMBL233929 | GALUTEOLIN | — | 1 | 4.68 |
| CHEMBL395414 | DISOGLUSIDE | 2.0 | 1 | 4.52 |
| CHEMBL242341 | FORMONONETIN | 2.0 | 1 | 4.22 |
| CHEMBL486422 | DAIDZIN | — | 1 | 4.21 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.09 |
| CHEMBL487017 | APIGETRIN | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL453981 | GANODERIC ACID F | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL233929 | GALUTEOLIN | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL395414 | DISOGLUSIDE | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL242341 | FORMONONETIN | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL486422 | DAIDZIN | IC50 | = | 61200.0 | nM | 4.21 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 80800.0 | nM | 4.09 |
| CHEMBL487017 | APIGETRIN | IC50 | = | 90600.0 | nM | 4.04 |