Assay Detail
Binding
CHEMBL3291950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scintillation counting
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.26 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089318 | OPICAPONE | 4.0 | 2 | 8.82 |
| CHEMBL3289430 | — | — | 2 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089318 | OPICAPONE | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1089318 | OPICAPONE | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL3289430 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL3289430 | — | Ki | = | 63095.73 | nM | 4.20 |