Assay Detail
Binding
CHEMBL3292010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 amino acid) after 45 mins by spectrophotometry relative to control
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.24 | 4.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491960 | CAMBINOL | — | 1 | 4.32 |
| CHEMBL3290218 | — | — | 1 | 4.31 |
| CHEMBL595354 | — | — | 1 | 4.24 |
| CHEMBL3290210 | — | — | 1 | 4.22 |
| CHEMBL3290220 | — | — | 1 | 4.10 |
| CHEMBL3290211 | — | — | 1 | - |
| CHEMBL3290212 | — | — | 1 | - |
| CHEMBL3290213 | — | — | 1 | - |
| CHEMBL3290214 | — | — | 1 | - |
| CHEMBL3290215 | — | — | 1 | - |
| CHEMBL3290216 | — | — | 1 | - |
| CHEMBL3290217 | — | — | 1 | - |
| CHEMBL3290219 | — | — | 1 | - |
| CHEMBL3290209 | — | — | 1 | - |
| CHEMBL3290222 | — | — | 1 | - |
| CHEMBL3290223 | — | — | 1 | - |
| CHEMBL3290224 | — | — | 1 | - |
| CHEMBL3290221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491960 | CAMBINOL | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL3290218 | — | IC50 | = | 49120.0 | nM | 4.31 |
| CHEMBL595354 | — | IC50 | = | 58100.0 | nM | 4.24 |
| CHEMBL3290210 | — | IC50 | = | 60310.0 | nM | 4.22 |
| CHEMBL3290220 | — | IC50 | = | 79870.0 | nM | 4.10 |
| CHEMBL3290211 | — | IC50 | - | — | - | |
| CHEMBL3290212 | — | IC50 | - | — | - | |
| CHEMBL3290213 | — | IC50 | - | — | - | |
| CHEMBL3290214 | — | IC50 | - | — | - | |
| CHEMBL3290215 | — | IC50 | - | — | - | |
| CHEMBL3290216 | — | IC50 | - | — | - | |
| CHEMBL3290217 | — | IC50 | - | — | - | |
| CHEMBL3290219 | — | IC50 | - | — | - | |
| CHEMBL3290209 | — | IC50 | - | — | - | |
| CHEMBL3290222 | — | IC50 | - | — | - | |
| CHEMBL3290223 | — | IC50 | - | — | - | |
| CHEMBL3290224 | — | IC50 | - | — | - | |
| CHEMBL3290221 | — | IC50 | - | — | - |