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Assay Detail

CHEMBL3292179

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IKKbeta kinase (unknown origin) by Lance ULight system
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors.
Park CH, Lee C, Yang JS, Joe BY, Chun K, Kim H, Kim HY, Kang JS, Lee JI, Kim MH, Han G.
Bioorg Med Chem Lett (2014) 24 : 2655 -2660
PubMed 24813730 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 7.21 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129857 AS-602868 1.0 1 7.21
CHEMBL3290618 1 -
CHEMBL3290634 1 -
CHEMBL3290632 1 -
CHEMBL3290631 1 -
CHEMBL3290630 1 -
CHEMBL3290629 1 -
CHEMBL3290624 1 -
CHEMBL3290623 1 -
CHEMBL3290622 1 -
CHEMBL3290621 1 -
CHEMBL3290620 1 -
CHEMBL3290613 1 -
CHEMBL3290617 1 -
CHEMBL3290616 1 -
CHEMBL3290615 1 -
CHEMBL3290614 1 -
CHEMBL3290625 1 -
CHEMBL3290626 1 -
CHEMBL3290627 1 -
CHEMBL3290628 1 -
CHEMBL3290633 1 -
CHEMBL3290619 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129857 AS-602868 IC50 = 62.0 nM 7.21
CHEMBL3290618 IC50 - -
CHEMBL3290634 IC50 - -
CHEMBL3290632 IC50 - -
CHEMBL3290631 IC50 - -
CHEMBL3290630 IC50 - -
CHEMBL3290629 IC50 - -
CHEMBL3290624 IC50 - -
CHEMBL3290623 IC50 - -
CHEMBL3290622 IC50 - -
CHEMBL3290621 IC50 - -
CHEMBL3290620 IC50 - -
CHEMBL3290613 IC50 - -
CHEMBL3290617 IC50 - -
CHEMBL3290616 IC50 - -
CHEMBL3290615 IC50 - -
CHEMBL3290614 IC50 - -
CHEMBL3290625 IC50 > 50000.0 nM -
CHEMBL3290626 IC50 > 50000.0 nM -
CHEMBL3290627 IC50 > 50000.0 nM -
CHEMBL3290628 IC50 > 50000.0 nM -
CHEMBL3290633 IC50 > 50000.0 nM -
CHEMBL3290619 IC50 - -