Assay Detail
Binding
CHEMBL3292514
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Inhibition of human ERG
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.80 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288030 | — | — | 1 | 5.20 |
| CHEMBL3288029 | — | — | 1 | 4.70 |
| CHEMBL3287739 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288030 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL3288029 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3287739 | — | IC50 | = | 31622.78 | nM | 4.50 |