Assay Detail
Binding
CHEMBL3292604
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Blockade of Influenza A virus (A/England/195/2009(H1N1)) full length M2 proton channel expressed in HEK cells after 3 mins by voltage clamp technique
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/07/2009(H1N1)) |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.80 |
| CHEMBL1170792 | — | — | 1 | 5.60 |
| CHEMBL1170182 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1170792 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1170182 | — | IC50 | = | 7000.0 | nM | 5.16 |