Assay Detail
Binding
CHEMBL3292804
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Inhibition of human recombinant carbonic anhydrase 12 pretreated for 15 mins by stopped flow CO2 hydrase assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.65 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3291002 | — | — | 1 | 7.21 |
| CHEMBL3291013 | — | — | 1 | 7.19 |
| CHEMBL3291012 | — | — | 1 | 7.12 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.06 |
| CHEMBL3291010 | — | — | 1 | 7.06 |
| CHEMBL3291007 | — | — | 1 | 7.04 |
| CHEMBL3291004 | — | — | 1 | 6.65 |
| CHEMBL3291003 | — | — | 1 | 6.56 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 6.50 |
| CHEMBL3291006 | — | — | 1 | 6.42 |
| CHEMBL3291009 | — | — | 1 | 6.41 |
| CHEMBL3291005 | — | — | 1 | 6.34 |
| CHEMBL3291001 | — | — | 1 | 6.33 |
| CHEMBL3291011 | — | — | 1 | 6.32 |
| CHEMBL3291008 | — | — | 1 | 6.10 |
| CHEMBL3291000 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3291002 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3291013 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3291012 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3291010 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3291007 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3291004 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3291003 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL3291006 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL3291009 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL3291005 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL3291001 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL3291011 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL3291008 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL3291000 | — | IC50 | = | 855.0 | nM | 6.07 |