Assay Detail
Functional
CHEMBL3292808
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Cytotoxicity against mouse J774 cells assessed as reduction in cell viability
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.09 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3291011 | — | — | 1 | 5.77 |
| CHEMBL3291009 | — | — | 1 | 5.31 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 5.11 |
| CHEMBL3291010 | — | — | 1 | 4.92 |
| CHEMBL3291012 | — | — | 1 | 4.92 |
| CHEMBL3291013 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3291011 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3291009 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3291010 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3291012 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3291013 | — | IC50 | = | 32000.0 | nM | 4.50 |