Assay Detail
Binding
CHEMBL3292879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.61 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207197 | OLCEGEPANT | 2.0 | 1 | 10.59 |
| CHEMBL3288288 | — | — | 1 | 9.82 |
| CHEMBL3288289 | — | — | 1 | 7.02 |
| CHEMBL3288290 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207197 | OLCEGEPANT | EC50 | = | 0.026 | nM | 10.59 |
| CHEMBL3288288 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3288289 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3288290 | — | EC50 | = | 100.0 | nM | 7.00 |