Assay Detail
Binding
CHEMBL3293049
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Inhibition of human CYP11B2 expressed in hamster V79MZh cells using deoxycorticosterone as substrate
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.57 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 9.70 |
| CHEMBL3287192 | — | — | 1 | 9.22 |
| CHEMBL3287178 | — | — | 1 | 9.15 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 9.10 |
| CHEMBL1765205 | — | — | 1 | 8.96 |
| CHEMBL3287193 | — | — | 1 | 8.77 |
| CHEMBL3287188 | — | — | 1 | 8.66 |
| CHEMBL3287179 | — | — | 1 | 8.55 |
| CHEMBL3287187 | — | — | 1 | 8.52 |
| CHEMBL3287194 | — | — | 1 | 7.89 |
| CHEMBL3287189 | — | — | 1 | 7.85 |
| CHEMBL3287185 | — | — | 1 | 7.80 |
| CHEMBL3287190 | — | — | 1 | 7.64 |
| CHEMBL3287180 | — | — | 1 | 7.52 |
| CHEMBL3287184 | — | — | 1 | 7.44 |
| CHEMBL3287186 | — | — | 1 | 7.26 |
| CHEMBL3287169 | — | — | 1 | 7.22 |
| CHEMBL3287183 | — | — | 1 | 7.21 |
| CHEMBL3287191 | — | — | 1 | 7.11 |
| CHEMBL3287181 | — | — | 1 | 6.82 |
| CHEMBL3287170 | — | — | 1 | 6.64 |
| CHEMBL3287182 | — | — | 1 | 6.37 |
| CHEMBL3286405 | — | — | 1 | 6.22 |
| CHEMBL3287171 | — | — | 1 | 5.89 |
| CHEMBL3287175 | — | — | 1 | 5.84 |
| CHEMBL3287174 | — | — | 1 | 5.55 |
| CHEMBL3287176 | — | — | 1 | 5.51 |
| CHEMBL3287177 | — | — | 1 | - |
| CHEMBL3287173 | — | — | 1 | - |
| CHEMBL3287172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3287192 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3287178 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1765205 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3287193 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3287188 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3287179 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3287187 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3287194 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3287189 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3287185 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3287190 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3287180 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3287184 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3287186 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3287169 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3287183 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3287191 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3287181 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL3287170 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3287182 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL3286405 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL3287171 | — | IC50 | = | 1285.0 | nM | 5.89 |
| CHEMBL3287175 | — | IC50 | = | 1433.0 | nM | 5.84 |
| CHEMBL3287174 | — | IC50 | = | 2833.0 | nM | 5.55 |
| CHEMBL3287176 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL3287177 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3287173 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3287172 | — | IC50 | > | 5000.0 | nM | - |