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Assay Detail

CHEMBL3293222

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-ketanserin from human 5HT2A receptor expressed in HEK293 cells by competitive binding assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Functionally selective dopamine D₂, D₃ receptor partial agonists.
Möller D, Kling RC, Skultety M, Leuner K, Hübner H, Gmeiner P.
J Med Chem (2014) 57 : 4861 -4875
PubMed 24831693 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.58 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1112 ARIPIPRAZOLE 4.0 1 8.40
CHEMBL3287403 2 8.40
CHEMBL3287404 1 8.10
CHEMBL3287396 1 7.80
CHEMBL2028019 CARIPRAZINE 4.0 1 7.66
CHEMBL3287395 1 7.66
CHEMBL3287402 1 7.25
CHEMBL3287406 1 7.09
CHEMBL3287397 1 6.62
CHEMBL3287405 1 6.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1112 ARIPIPRAZOLE Ki = 4.0 nM 8.40
CHEMBL3287403 Ki = 4.0 nM 8.40
CHEMBL3287403 Ki = 7.7 nM 8.11
CHEMBL3287404 Ki = 7.9 nM 8.10
CHEMBL3287396 Ki = 16.0 nM 7.80
CHEMBL2028019 CARIPRAZINE Ki = 22.0 nM 7.66
CHEMBL3287395 Ki = 22.0 nM 7.66
CHEMBL3287402 Ki = 56.0 nM 7.25
CHEMBL3287406 Ki = 81.0 nM 7.09
CHEMBL3287397 Ki = 240.0 nM 6.62
CHEMBL3287405 Ki = 490.0 nM 6.31