Assay Detail
Binding
CHEMBL3293240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 (unknown origin)
13
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
β-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 6.39 |
| Inhibition | 3 | - | - |
| Ki | 2 | 5.23 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506814 | PUNICALAGIN | — | 1 | 6.39 |
| CHEMBL450745 | EUGENIIN | — | 2 | 5.51 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | — | 2 | 5.42 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 5.41 |
| CHEMBL3287409 | — | — | 2 | 5.37 |
| CHEMBL498456 | BOERAVINONE D | — | 2 | 5.32 |
| CHEMBL3287407 | — | — | 2 | 4.21 |
| CHEMBL3287408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506814 | PUNICALAGIN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL450745 | EUGENIIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3287409 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL498456 | BOERAVINONE D | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | Ki | = | 5130.0 | nM | 5.29 |
| CHEMBL450745 | EUGENIIN | Ki | = | 6840.0 | nM | 5.17 |
| CHEMBL3287407 | — | IC50 | = | 62210.0 | nM | 4.21 |
| CHEMBL3287408 | — | IC50 | > | 3000000.0 | nM | - |
| CHEMBL498456 | BOERAVINONE D | Inhibition | - | % | - | |
| CHEMBL3287407 | — | Inhibition | - | % | - | |
| CHEMBL3287409 | — | Inhibition | - | % | - |