Assay Detail
Binding
CHEMBL3293383
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Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.83 | 7.92 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289604 | — | — | 2 | 7.92 |
| CHEMBL3289606 | — | — | 2 | 6.44 |
| CHEMBL3289605 | — | — | 2 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289604 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3289606 | — | EC50 | = | 365.0 | nM | 6.44 |
| CHEMBL3289605 | — | EC50 | = | 763.0 | nM | 6.12 |
| CHEMBL3289604 | — | Activity | - | — | - | |
| CHEMBL3289605 | — | Activity | - | — | - | |
| CHEMBL3289606 | — | Activity | - | — | - |