Assay Detail
Binding
CHEMBL3294182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DGAT2 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.00 | 5.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287865 | — | — | 1 | 5.00 |
| CHEMBL3233884 | — | — | 1 | - |
| CHEMBL3287878 | — | — | 1 | - |
| CHEMBL3233872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287865 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3233884 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287878 | — | Inhibition | - | % | - | |
| CHEMBL3233872 | — | IC50 | > | 50000.0 | nM | - |