Assay Detail
Binding
CHEMBL3294184
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Inhibition of human ACAT2 expressed in Sf9 insect cells using [14C]-oleoyl-CoA by scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.31 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287865 | — | — | 1 | 5.70 |
| CHEMBL3233872 | — | — | 1 | 5.52 |
| CHEMBL3287864 | — | — | 1 | 5.30 |
| CHEMBL3287878 | — | — | 1 | 5.02 |
| CHEMBL3233884 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287865 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3233872 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3287864 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3287878 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3233884 | — | IC50 | = | 9700.0 | nM | 5.01 |