Assay Detail
Binding
CHEMBL3294188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.60 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287876 | — | — | 1 | 7.70 |
| CHEMBL3287878 | — | — | 1 | 7.70 |
| CHEMBL3287884 | — | — | 1 | 7.50 |
| CHEMBL3287875 | — | — | 1 | 7.48 |
| CHEMBL2036730 | — | — | 1 | 7.44 |
| CHEMBL3233872 | — | — | 1 | 7.43 |
| CHEMBL3287865 | — | — | 1 | 7.37 |
| CHEMBL3287890 | — | — | 1 | 7.28 |
| CHEMBL3287898 | — | — | 1 | 7.19 |
| CHEMBL3233884 | — | — | 1 | 7.19 |
| CHEMBL3287874 | — | — | 1 | 7.16 |
| CHEMBL3287897 | — | — | 1 | 7.07 |
| CHEMBL3287864 | — | — | 1 | 7.04 |
| CHEMBL3287882 | — | — | 1 | 7.04 |
| CHEMBL3287894 | — | — | 1 | 7.00 |
| CHEMBL3287867 | — | — | 1 | 6.96 |
| CHEMBL3287896 | — | — | 1 | 6.96 |
| CHEMBL3287877 | — | — | 1 | 6.85 |
| CHEMBL3287883 | — | — | 1 | 6.64 |
| CHEMBL3287893 | — | — | 1 | 6.54 |
| CHEMBL3287886 | — | — | 1 | 6.52 |
| CHEMBL3287887 | — | — | 1 | 6.44 |
| CHEMBL3287892 | — | — | 1 | 6.39 |
| CHEMBL3287868 | — | — | 1 | 6.35 |
| CHEMBL3287866 | — | — | 1 | 6.28 |
| CHEMBL3286412 | — | — | 1 | 6.25 |
| CHEMBL3287869 | — | — | 1 | 6.24 |
| CHEMBL3287881 | — | — | 1 | 6.24 |
| CHEMBL3287889 | — | — | 1 | 6.20 |
| CHEMBL3287895 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287876 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3287878 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3287884 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3287875 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2036730 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3233872 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3287865 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3287890 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3287898 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3233884 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3287874 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3287897 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3287882 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3287864 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3287894 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3287867 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3287896 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3287877 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3287883 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3287893 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3287886 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3287887 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3287892 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3287868 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3287866 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3286412 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3287869 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3287881 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3287889 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3287895 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3287891 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3287885 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3287873 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3287861 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3288152 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3287862 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3287888 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3287870 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3287880 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3287860 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287879 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287859 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287858 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287863 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287871 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3287872 | — | IC50 | > | 10000.0 | nM | - |