Assay Detail
Binding
CHEMBL3294302
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Inhibition of SphK1 (unknown origin)
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 5.30 | 5.30 |
| IC50 | 1 | 7.40 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287035 | — | — | 1 | 7.40 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287035 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | Ki | = | 5000.0 | nM | 5.30 |