Assay Detail

CHEMBL3294367

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Functional

Antiviral activity against Hepatitis C virus genotype 4a replicon containing Hepatitis C virus genotype 1b Con1 replicon

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect.

Belema M, Meanwell NA.
J Med Chem (2014) 57 : 5057 -5071
PubMed 24749835 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	10.92	10.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2023898	DACLATASVIR	4.0	1	10.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2023898	DACLATASVIR	EC50	=	0.012	nM	10.92