Assay Detail
Binding
CHEMBL3294392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 kinase (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.68 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290626 | — | — | 1 | 7.19 |
| CHEMBL3290634 | — | — | 1 | 7.07 |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | 6.99 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 6.92 |
| CHEMBL3290631 | — | — | 1 | 6.88 |
| CHEMBL3290625 | — | — | 1 | 6.76 |
| CHEMBL3290633 | — | — | 1 | 6.76 |
| CHEMBL3290628 | — | — | 1 | 6.68 |
| CHEMBL3290629 | — | — | 1 | 6.31 |
| CHEMBL3290632 | — | — | 1 | 6.27 |
| CHEMBL3290627 | — | — | 1 | 6.17 |
| CHEMBL3290630 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290626 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3290634 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL124660 | TANDUTINIB | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3290631 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3290625 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3290633 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3290628 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3290629 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL3290632 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3290627 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL3290630 | — | IC50 | = | 750.0 | nM | 6.12 |