Assay Detail
Binding
CHEMBL3294635
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Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 mins
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.50 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 8.82 |
| CHEMBL3290658 | — | — | 1 | 7.80 |
| CHEMBL3290663 | — | — | 1 | 7.62 |
| CHEMBL3290657 | — | — | 1 | 7.40 |
| CHEMBL301499 | — | — | 1 | 7.26 |
| CHEMBL419393 | — | — | 1 | 6.71 |
| CHEMBL3290659 | — | — | 1 | 6.63 |
| CHEMBL3290650 | — | — | 1 | 6.60 |
| CHEMBL3290662 | — | — | 1 | 6.57 |
| CHEMBL49935 | ARISTEROMYCIN | — | 1 | 6.52 |
| CHEMBL3290668 | — | — | 1 | 6.34 |
| CHEMBL3290667 | — | — | 1 | 6.01 |
| CHEMBL3290664 | — | — | 1 | 5.91 |
| CHEMBL3290655 | — | — | 1 | 5.67 |
| CHEMBL3290660 | — | — | 1 | 5.44 |
| CHEMBL299961 | — | — | 1 | 5.38 |
| CHEMBL3290656 | — | — | 1 | 5.32 |
| CHEMBL3290665 | — | — | 1 | 5.01 |
| CHEMBL3290661 | — | — | 1 | - |
| CHEMBL3290666 | — | — | 1 | - |
| CHEMBL3290649 | — | — | 1 | - |
| CHEMBL3290652 | — | — | 1 | - |
| CHEMBL3290654 | — | — | 1 | - |
| CHEMBL3290653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3290658 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3290663 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3290657 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL301499 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL419393 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL3290659 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL3290650 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3290662 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL49935 | ARISTEROMYCIN | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL3290668 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL3290667 | — | IC50 | = | 976.0 | nM | 6.01 |
| CHEMBL3290664 | — | IC50 | = | 1223.0 | nM | 5.91 |
| CHEMBL3290655 | — | IC50 | = | 2124.0 | nM | 5.67 |
| CHEMBL3290660 | — | IC50 | = | 3644.0 | nM | 5.44 |
| CHEMBL299961 | — | IC50 | = | 4125.0 | nM | 5.38 |
| CHEMBL3290656 | — | IC50 | = | 4827.0 | nM | 5.32 |
| CHEMBL3290665 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL3290661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290649 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290652 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290654 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3290653 | — | IC50 | > | 10000.0 | nM | - |