Assay Detail
Binding
CHEMBL3294690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of NO711 from mouse GAT1 expressed in HEK293 cells by LC-MS/MS analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium- and chloride-dependent GABA transporter 1 (CHEMBL5445) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 4.69 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289578 | — | — | 1 | 5.04 |
| CHEMBL3289580 | — | — | 1 | 4.98 |
| CHEMBL3289568 | — | — | 1 | 4.96 |
| CHEMBL3289575 | — | — | 1 | 4.96 |
| CHEMBL3289576 | — | — | 1 | 4.95 |
| CHEMBL3289574 | — | — | 1 | 4.90 |
| CHEMBL3289573 | — | — | 1 | 4.81 |
| CHEMBL3289577 | — | — | 1 | 4.80 |
| CHEMBL3289566 | — | — | 1 | 4.79 |
| CHEMBL3289588 | — | — | 1 | 4.78 |
| CHEMBL3289579 | — | — | 1 | 4.78 |
| CHEMBL3289295 | — | — | 1 | 4.76 |
| CHEMBL3289571 | — | — | 1 | 4.75 |
| CHEMBL3289572 | — | — | 1 | 4.67 |
| CHEMBL3289570 | — | — | 1 | 4.67 |
| CHEMBL3289567 | — | — | 1 | 4.64 |
| CHEMBL3289581 | — | — | 1 | 4.62 |
| CHEMBL3289582 | — | — | 1 | 4.60 |
| CHEMBL3289585 | — | — | 1 | 4.59 |
| CHEMBL75035 | — | — | 1 | 4.56 |
| CHEMBL3289583 | — | — | 1 | 4.53 |
| CHEMBL3289586 | — | — | 1 | 4.52 |
| CHEMBL3289569 | — | — | 1 | 4.51 |
| CHEMBL3289584 | — | — | 1 | 4.49 |
| CHEMBL3289587 | — | — | 1 | 4.47 |
| CHEMBL3289294 | — | — | 1 | 4.20 |
| CHEMBL3289293 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289578 | — | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL3289580 | — | Ki | = | 10471.29 | nM | 4.98 |
| CHEMBL3289568 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL3289575 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL3289576 | — | Ki | = | 11220.18 | nM | 4.95 |
| CHEMBL3289574 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL3289573 | — | Ki | = | 15488.17 | nM | 4.81 |
| CHEMBL3289577 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL3289566 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL3289588 | — | Ki | = | 16595.87 | nM | 4.78 |
| CHEMBL3289579 | — | Ki | = | 16595.87 | nM | 4.78 |
| CHEMBL3289295 | — | Ki | = | 17378.01 | nM | 4.76 |
| CHEMBL3289571 | — | Ki | = | 17782.79 | nM | 4.75 |
| CHEMBL3289572 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL3289570 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL3289567 | — | Ki | = | 22908.68 | nM | 4.64 |
| CHEMBL3289581 | — | Ki | = | 23988.33 | nM | 4.62 |
| CHEMBL3289582 | — | Ki | = | 25118.86 | nM | 4.60 |
| CHEMBL3289585 | — | Ki | = | 25703.96 | nM | 4.59 |
| CHEMBL75035 | — | Ki | = | 27542.29 | nM | 4.56 |
| CHEMBL3289583 | — | Ki | = | 29512.09 | nM | 4.53 |
| CHEMBL3289586 | — | Ki | = | 30199.52 | nM | 4.52 |
| CHEMBL3289569 | — | Ki | = | 30902.95 | nM | 4.51 |
| CHEMBL3289584 | — | Ki | = | 32359.37 | nM | 4.49 |
| CHEMBL3289587 | — | Ki | = | 33884.42 | nM | 4.47 |
| CHEMBL3289294 | — | Ki | = | 63095.73 | nM | 4.20 |
| CHEMBL3289293 | — | Ki | = | 66069.34 | nM | 4.18 |