Assay Detail
Binding
CHEMBL3295081
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Spiperone from human dopamine D2 short receptor expressed in CHO cells by competitive binding assay
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functionally selective dopamine D₂, D₃ receptor partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.31 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287403 | — | — | 2 | 9.60 |
| CHEMBL3287405 | — | — | 1 | 9.49 |
| CHEMBL2028019 | CARIPRAZINE | 4.0 | 1 | 9.39 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.35 |
| CHEMBL3287392 | — | — | 1 | 8.68 |
| CHEMBL3287404 | — | — | 1 | 8.64 |
| CHEMBL3287396 | — | — | 1 | 8.64 |
| CHEMBL3287397 | — | — | 1 | 8.49 |
| CHEMBL3287395 | — | — | 1 | 8.17 |
| CHEMBL3287406 | — | — | 1 | 8.17 |
| CHEMBL3287399 | — | — | 1 | 8.09 |
| CHEMBL3287394 | — | — | 1 | 8.00 |
| CHEMBL3287401 | — | — | 1 | 7.85 |
| CHEMBL3287402 | — | — | 1 | 7.85 |
| CHEMBL3287400 | — | — | 1 | 7.82 |
| CHEMBL3287393 | — | — | 1 | 7.80 |
| CHEMBL3287398 | — | — | 1 | 7.62 |
| CHEMBL3287391 | — | — | 1 | 7.52 |
| CHEMBL3287390 | — | — | 1 | 7.41 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287403 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3287405 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL2028019 | CARIPRAZINE | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL3287403 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3287392 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3287404 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3287396 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3287397 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL3287406 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL3287395 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL3287399 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL3287394 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3287401 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3287402 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3287400 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3287393 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3287398 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3287391 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3287390 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 70.0 | nM | 7.16 |