Assay Detail
Binding
CHEMBL3295083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Spiperone from human dopamine D4.4 receptor expressed in CHO cells by competitive binding assay
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functionally selective dopamine D₂, D₃ receptor partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.61 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287392 | — | — | 1 | 8.36 |
| CHEMBL3287403 | — | — | 2 | 8.28 |
| CHEMBL3287405 | — | — | 1 | 8.24 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.07 |
| CHEMBL3287406 | — | — | 1 | 8.03 |
| CHEMBL3287391 | — | — | 1 | 7.80 |
| CHEMBL3287393 | — | — | 1 | 7.80 |
| CHEMBL3287399 | — | — | 1 | 7.75 |
| CHEMBL3287404 | — | — | 1 | 7.62 |
| CHEMBL3287401 | — | — | 1 | 7.54 |
| CHEMBL3287394 | — | — | 1 | 7.48 |
| CHEMBL3287396 | — | — | 1 | 7.46 |
| CHEMBL3287398 | — | — | 1 | 7.39 |
| CHEMBL3287395 | — | — | 1 | 7.33 |
| CHEMBL3287397 | — | — | 1 | 7.24 |
| CHEMBL3287400 | — | — | 1 | 7.11 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.09 |
| CHEMBL3287402 | — | — | 1 | 7.05 |
| CHEMBL2028019 | CARIPRAZINE | 4.0 | 1 | 6.96 |
| CHEMBL3287390 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287392 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3287403 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL3287405 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3287403 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3287406 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL3287391 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3287393 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3287399 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3287404 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3287401 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3287394 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3287396 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3287398 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3287395 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL3287397 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3287400 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL3287402 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL2028019 | CARIPRAZINE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3287390 | — | Ki | = | 130.0 | nM | 6.89 |