Assay Detail
Binding
CHEMBL3295137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 12-LO in human neutrophils
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.13 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 5.14 |
| CHEMBL2413471 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2413471 | — | IC50 | = | 7700.0 | nM | 5.11 |