Assay Detail
Binding
CHEMBL3295141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinone
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear factor erythroid 2-related factor 2 (CHEMBL1075094) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.41 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128729 | — | — | 1 | 6.05 |
| CHEMBL3290186 | — | — | 1 | 5.51 |
| CHEMBL3290185 | — | — | 1 | 5.07 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.00 |
| CHEMBL3290439 | — | — | 1 | - |
| CHEMBL318743 | TETRAHYDROCURCUMIN | — | 1 | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | - |
| CHEMBL2413471 | — | — | 1 | - |
| CHEMBL2392187 | — | — | 1 | - |
| CHEMBL2392186 | — | — | 1 | - |
| CHEMBL2392188 | — | — | 1 | - |
| CHEMBL3290441 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128729 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3290186 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3290185 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL140 | CURCUMIN | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3290439 | — | EC50 | - | — | - | |
| CHEMBL318743 | TETRAHYDROCURCUMIN | EC50 | - | — | - | |
| CHEMBL180239 | CURCUMIN PYRAZOLE | EC50 | - | — | - | |
| CHEMBL2413471 | — | EC50 | - | — | - | |
| CHEMBL2392187 | — | EC50 | - | — | - | |
| CHEMBL2392186 | — | EC50 | - | — | - | |
| CHEMBL2392188 | — | EC50 | - | — | - | |
| CHEMBL3290441 | — | EC50 | - | — | - |