Assay Detail
Binding
CHEMBL3295154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2-mediated PGF2alpha formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| IC50 | 2 | 6.91 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290441 | — | — | 1 | 7.89 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.92 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | - |
| CHEMBL2413471 | — | — | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290441 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | Inhibition | - | % | - | |
| CHEMBL2413471 | — | Inhibition | - | % | - | |
| CHEMBL140 | CURCUMIN | Inhibition | - | % | - |