Assay Detail
Binding
CHEMBL3295172
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Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.72 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289100 | — | — | 1 | 6.40 |
| CHEMBL3289097 | — | — | 1 | 6.40 |
| CHEMBL566929 | BETA-ELEMONIC ACID | — | 1 | 6.05 |
| CHEMBL3289107 | — | — | 1 | 6.05 |
| CHEMBL3289103 | — | — | 1 | 6.00 |
| CHEMBL3289096 | — | — | 1 | 5.96 |
| CHEMBL3289098 | — | — | 1 | 5.92 |
| CHEMBL29097 | — | — | 1 | 5.62 |
| CHEMBL236906 | — | — | 1 | 5.52 |
| CHEMBL3289099 | — | — | 1 | 5.52 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | — | 1 | 5.52 |
| CHEMBL237111 | AKBA | -1.0 | 1 | 5.52 |
| CHEMBL267225 | BOSWELLIC ACID | 2.0 | 1 | 5.30 |
| CHEMBL3289105 | — | — | 1 | 5.07 |
| CHEMBL3289106 | — | — | 1 | 5.00 |
| CHEMBL3289104 | — | — | 1 | - |
| CHEMBL3289102 | — | — | 1 | - |
| CHEMBL3289101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289100 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3289097 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL566929 | BETA-ELEMONIC ACID | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3289107 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3289103 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3289096 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3289098 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL29097 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL236906 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3289099 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL237111 | AKBA | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL267225 | BOSWELLIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3289105 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3289106 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3289104 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3289102 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3289101 | — | IC50 | > | 10000.0 | nM | - |