Assay Detail

CHEMBL3295249

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Induction of insulin secretion in human GPR40 knock-in mouse pancreatic islets

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Pancreatic islets (CHEMBL613588) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Pancreatic islets (CHEMBL613588) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Pancreatic islets

CHEMBL613588

Anchored from Assay target.

Protein identity Pancreatic islets

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Confidence	1 — Organism
Curated By	Autocuration

Target

Pancreatic islets (CHEMBL613588) ↗

Type	TISSUE
Organism	Mus musculus

Publication

Optimization of GPR40 Agonists for Type 2 Diabetes.

Liu JJ, Wang Y, Ma Z, Schmitt M, Zhu L, Brown SP, Dransfield PJ, Sun Y, Sharma R, Guo Q, Zhuang R, Zhang J, Luo J, Tonn GR, Wong S, Swaminath G, Medina JC, Lin DC, Houze JB.
ACS Med Chem Lett (2014) 5 : 517 -521
PubMed 24900872 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.26	7.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3287574	—	—	1	7.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3287574	—	EC50	=	55.0	nM	7.26