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Assay Detail

CHEMBL3295441

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and anticancer activity of some novel 5,6-fused hybrids of juglone based 1,4-naphthoquinones.
Mallavadhani UV, Prasad CV, Shrivastava S, Naidu VG.
Eur J Med Chem (2014) 83 : 84 -91
PubMed 24953027 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.71 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 4.96
CHEMBL3288601 1 4.94
CHEMBL3288607 1 4.93
CHEMBL295316 PLUMBAGIN 1.0 1 4.91
CHEMBL3288602 1 4.87
CHEMBL3288599 1 4.83
CHEMBL43612 JUGLONE 1 4.78
CHEMBL3288605 1 4.63
CHEMBL3288598 1 4.62
CHEMBL44657 ETOPOSIDE 4.0 1 4.62
CHEMBL3288604 1 4.61
CHEMBL3288606 1 4.54
CHEMBL3288603 1 4.47
CHEMBL3288600 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 10900.0 nM 4.96
CHEMBL3288601 IC50 = 11600.0 nM 4.94
CHEMBL3288607 IC50 = 11700.0 nM 4.93
CHEMBL295316 PLUMBAGIN IC50 = 12200.0 nM 4.91
CHEMBL3288602 IC50 = 13400.0 nM 4.87
CHEMBL3288599 IC50 = 14700.0 nM 4.83
CHEMBL43612 JUGLONE IC50 = 16500.0 nM 4.78
CHEMBL3288605 IC50 = 23200.0 nM 4.63
CHEMBL3288598 IC50 = 24000.0 nM 4.62
CHEMBL44657 ETOPOSIDE IC50 = 23900.0 nM 4.62
CHEMBL3288604 IC50 = 24300.0 nM 4.61
CHEMBL3288606 IC50 = 28800.0 nM 4.54
CHEMBL3288603 IC50 = 33800.0 nM 4.47
CHEMBL3288600 IC50 = 58200.0 nM 4.24