Assay Detail
Binding
CHEMBL3295545
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Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.77 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287849 | — | — | 1 | 6.55 |
| CHEMBL3287856 | — | — | 1 | 6.44 |
| CHEMBL3287854 | — | — | 1 | 6.41 |
| CHEMBL3287851 | — | — | 2 | 6.36 |
| CHEMBL3287857 | — | — | 1 | 6.35 |
| CHEMBL3287847 | — | — | 1 | 6.24 |
| CHEMBL3287852 | — | — | 1 | 6.11 |
| CHEMBL311761 | — | — | 1 | 6.10 |
| CHEMBL3287850 | — | — | 1 | 5.99 |
| CHEMBL3287853 | — | — | 1 | 5.97 |
| CHEMBL3287855 | — | — | 1 | 5.90 |
| CHEMBL144416 | — | — | 1 | 5.70 |
| CHEMBL3287844 | — | — | 1 | 5.68 |
| CHEMBL877 | TRANEXAMIC ACID | 4.0 | 1 | 5.51 |
| CHEMBL3287843 | — | — | 1 | 4.40 |
| CHEMBL1046 | AMINOCAPROIC ACID | 4.0 | 1 | 4.40 |
| CHEMBL3287842 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287849 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3287856 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3287854 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3287851 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3287857 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3287847 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3287852 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL311761 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3287850 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3287853 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3287855 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3287851 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL144416 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3287844 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL877 | TRANEXAMIC ACID | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1046 | AMINOCAPROIC ACID | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3287843 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3287842 | — | IC50 | = | 100000.0 | nM | 4.00 |