Assay Detail
Functional
CHEMBL3295772
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Inhibition of Influenza A virus (A/Parma/24/2009(H1N1)) infected in MDCK cells after 48 hrs by plaque reduction assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Parma/24/2009(H1N1)) |
| Cell Type | MDCK |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of small-molecule inhibitors of influenza virus polymerase: from thiophene-3-carboxamide to polyamido scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.46 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288059 | — | — | 1 | 4.66 |
| CHEMBL3288054 | — | — | 1 | 4.64 |
| CHEMBL3288056 | — | — | 1 | 4.60 |
| CHEMBL3288254 | — | — | 1 | 4.37 |
| CHEMBL3288048 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288059 | — | EC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL3288054 | — | EC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL3288056 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3288254 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3288048 | — | EC50 | = | 95500.0 | nM | 4.02 |