Assay Detail
Functional
CHEMBL3296010
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Cytotoxicity against NQO-1 rich human A549 cells assessed as inhibition of cell viability after 2 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.03 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3291406 | — | — | 1 | 5.66 |
| CHEMBL3291400 | — | — | 1 | 5.64 |
| CHEMBL3291416 | — | — | 1 | 5.33 |
| CHEMBL3291405 | — | — | 1 | 5.31 |
| CHEMBL3291412 | — | — | 1 | 5.31 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.24 |
| CHEMBL3291413 | — | — | 1 | 5.22 |
| CHEMBL3291418 | — | — | 1 | 5.19 |
| CHEMBL1976537 | — | — | 1 | 5.13 |
| CHEMBL3291417 | — | — | 1 | 5.04 |
| CHEMBL3291404 | — | — | 1 | 5.00 |
| CHEMBL3291411 | — | — | 1 | 4.96 |
| CHEMBL3291403 | — | — | 1 | 4.92 |
| CHEMBL3291414 | — | — | 1 | 4.85 |
| CHEMBL3291401 | — | — | 1 | 4.80 |
| CHEMBL3291410 | — | — | 1 | 4.72 |
| CHEMBL3291402 | — | — | 1 | 4.70 |
| CHEMBL3291407 | — | — | 1 | 4.54 |
| CHEMBL3291409 | — | — | 1 | 4.51 |
| CHEMBL3291408 | — | — | 1 | 4.46 |
| CHEMBL3291415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3291406 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3291400 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3291416 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3291405 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3291412 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3291413 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3291418 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1976537 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3291417 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3291404 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3291411 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3291403 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3291414 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3291401 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3291410 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3291402 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3291407 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3291409 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3291408 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3291415 | — | IC50 | > | 50000.0 | nM | - |