Assay Detail
Functional
CHEMBL3296127
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Antiplasmodial activity against Plasmodium falciparum SB1 after 72 hrs by SYBR I method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.17 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.96 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.93 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.78 |
| CHEMBL3289799 | — | — | 1 | 7.37 |
| CHEMBL3289803 | — | — | 1 | 6.92 |
| CHEMBL3289817 | — | — | 1 | 6.79 |
| CHEMBL3289810 | — | — | 1 | 6.75 |
| CHEMBL3289806 | — | — | 1 | 6.66 |
| CHEMBL3289816 | — | — | 1 | 6.33 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 10.85 | nM | 7.96 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 11.81 | nM | 7.93 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL3289799 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL3289803 | — | IC50 | = | 121.3 | nM | 6.92 |
| CHEMBL3289817 | — | IC50 | = | 163.6 | nM | 6.79 |
| CHEMBL3289810 | — | IC50 | = | 177.8 | nM | 6.75 |
| CHEMBL3289806 | — | IC50 | = | 219.6 | nM | 6.66 |
| CHEMBL3289816 | — | IC50 | = | 471.9 | nM | 6.33 |
| CHEMBL1450 | ATOVAQUONE | IC50 | > | 2000.0 | nM | - |