Assay Detail
Functional
CHEMBL3296345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.05 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289672 | — | — | 1 | 8.74 |
| CHEMBL1738786 | — | — | 1 | 8.44 |
| CHEMBL3289670 | — | — | 1 | 8.41 |
| CHEMBL1956290 | — | — | 1 | 8.20 |
| CHEMBL3289671 | — | — | 1 | 7.92 |
| CHEMBL492529 | — | — | 1 | 6.58 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289672 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1738786 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3289670 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1956290 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3289671 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL492529 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | - | — | - |