Assay Detail
Functional
CHEMBL3296407
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Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.56 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289151 | — | — | 1 | 6.31 |
| CHEMBL2335108 | — | — | 1 | 6.04 |
| CHEMBL3289156 | — | — | 1 | 5.75 |
| CHEMBL3289154 | — | — | 1 | 5.59 |
| CHEMBL3289157 | — | — | 1 | 5.50 |
| CHEMBL3289150 | — | — | 1 | 5.46 |
| CHEMBL3286425 | — | — | 1 | 5.46 |
| CHEMBL3289149 | — | — | 1 | 5.45 |
| CHEMBL1337170 | — | — | 1 | 5.44 |
| CHEMBL3289152 | — | — | 1 | 5.43 |
| CHEMBL3289148 | — | — | 1 | 5.40 |
| CHEMBL3289153 | — | — | 1 | 5.39 |
| CHEMBL3289155 | — | — | 1 | 5.38 |
| CHEMBL3289158 | — | — | 1 | 5.22 |
| CHEMBL3289147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289151 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2335108 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3289156 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3289154 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3289157 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL3289150 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3286425 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL3289149 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL1337170 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3289152 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL3289148 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3289153 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL3289155 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL3289158 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL3289147 | — | IC50 | > | 10000.0 | nM | - |