Assay Detail
Functional
CHEMBL3296408
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Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.51 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2335108 | — | — | 1 | 5.79 |
| CHEMBL3289156 | — | — | 1 | 5.71 |
| CHEMBL3289152 | — | — | 1 | 5.60 |
| CHEMBL3289149 | — | — | 1 | 5.57 |
| CHEMBL3289150 | — | — | 1 | 5.57 |
| CHEMBL1337170 | — | — | 1 | 5.54 |
| CHEMBL3289153 | — | — | 1 | 5.54 |
| CHEMBL3289155 | — | — | 1 | 5.54 |
| CHEMBL3286425 | — | — | 1 | 5.51 |
| CHEMBL3289157 | — | — | 1 | 5.51 |
| CHEMBL3289154 | — | — | 1 | 5.48 |
| CHEMBL3289148 | — | — | 1 | 5.36 |
| CHEMBL3289151 | — | — | 1 | 5.26 |
| CHEMBL3289158 | — | — | 1 | 5.15 |
| CHEMBL3289147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2335108 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL3289156 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3289152 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL3289149 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3289150 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL1337170 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL3289153 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL3289155 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL3286425 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL3289157 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL3289154 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3289148 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL3289151 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL3289158 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL3289147 | — | IC50 | > | 10000.0 | nM | - |