Assay Detail
Functional
CHEMBL3296409
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Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ASPC1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.93 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289156 | — | — | 1 | 7.40 |
| CHEMBL3289154 | — | — | 1 | 5.99 |
| CHEMBL3289149 | — | — | 1 | 5.98 |
| CHEMBL3286425 | — | — | 1 | 5.98 |
| CHEMBL3289153 | — | — | 1 | 5.97 |
| CHEMBL3289150 | — | — | 1 | 5.94 |
| CHEMBL1337170 | — | — | 1 | 5.88 |
| CHEMBL3289148 | — | — | 1 | 5.86 |
| CHEMBL3289151 | — | — | 1 | 5.86 |
| CHEMBL3289152 | — | — | 1 | 5.85 |
| CHEMBL3289155 | — | — | 1 | 5.80 |
| CHEMBL2335108 | — | — | 1 | 5.72 |
| CHEMBL3289157 | — | — | 1 | 5.69 |
| CHEMBL3289158 | — | — | 1 | 5.07 |
| CHEMBL3289147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289156 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3289154 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3289149 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3286425 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3289153 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3289150 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL1337170 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3289148 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3289151 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3289152 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL3289155 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2335108 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL3289157 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL3289158 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL3289147 | — | IC50 | - | — | - |