Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3296499

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
24
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives.
Gazivoda Kraljević T, Ilić N, Stepanić V, Sappe L, Petranović J, Kraljević Pavelić S, Raić-Malić S.
Bioorg Med Chem Lett (2014) 24 : 2913 -2917
PubMed 24835982 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.42 6.52
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3288099 1 6.52
CHEMBL3288102 2 6.40
CHEMBL1835794 1 5.38
CHEMBL3288101 1 4.67
CHEMBL3288100 1 4.14
CHEMBL3288105 1 -
CHEMBL3288106 1 -
CHEMBL3288107 1 -
CHEMBL3288108 1 -
CHEMBL3288109 1 -
CHEMBL3288110 1 -
CHEMBL3288111 1 -
CHEMBL3288112 1 -
CHEMBL3288113 1 -
CHEMBL3288114 1 -
CHEMBL3288104 1 -
CHEMBL3288116 1 -
CHEMBL3288117 1 -
CHEMBL3288118 1 -
CHEMBL3288119 1 -
CHEMBL3288120 1 -
CHEMBL3288103 1 -
CHEMBL3288115 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3288099 IC50 = 300.0 nM 6.52
CHEMBL3288102 IC50 = 400.0 nM 6.40
CHEMBL1835794 IC50 = 4200.0 nM 5.38
CHEMBL3288101 IC50 = 21600.0 nM 4.67
CHEMBL3288100 IC50 = 72600.0 nM 4.14
CHEMBL3288105 IC50 > 100000.0 nM -
CHEMBL3288106 IC50 > 100000.0 nM -
CHEMBL3288107 IC50 > 100000.0 nM -
CHEMBL3288108 IC50 > 100000.0 nM -
CHEMBL3288109 IC50 > 100000.0 nM -
CHEMBL3288110 IC50 > 100000.0 nM -
CHEMBL3288111 IC50 > 100000.0 nM -
CHEMBL3288112 IC50 > 100000.0 nM -
CHEMBL3288113 IC50 > 100000.0 nM -
CHEMBL3288114 IC50 > 100000.0 nM -
CHEMBL3288115 IC50 > 100000.0 nM -
CHEMBL3288104 IC50 > 100000.0 nM -
CHEMBL3288117 IC50 > 100000.0 nM -
CHEMBL3288118 IC50 > 100000.0 nM -
CHEMBL3288119 IC50 > 100000.0 nM -
CHEMBL3288120 IC50 > 100000.0 nM -
CHEMBL3288103 IC50 > 100000.0 nM -
CHEMBL3288102 Activity - -
CHEMBL3288116 IC50 > 100000.0 nM -