Assay Detail
Functional
CHEMBL3297604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17beta-estradiol-induced in ERalpha positive human MCF7 cells proliferation assessed as [3H]-thymidine incorporation after 72 hrs by liquid scintillation counting
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.35 | 8.72 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.72 |
| CHEMBL3289514 | — | — | 1 | 7.75 |
| CHEMBL3289519 | — | — | 1 | 7.30 |
| CHEMBL464196 | SALPICHROLIDE A | — | 1 | 7.00 |
| CHEMBL470236 | SALPICHROLIDE G | — | 1 | 6.85 |
| CHEMBL3289515 | — | — | 1 | 6.48 |
| CHEMBL3289516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3289514 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3289519 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL464196 | SALPICHROLIDE A | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL470236 | SALPICHROLIDE G | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3289515 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3289516 | — | Inhibition | - | % | - |