Assay Detail
Binding
CHEMBL3297622
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Apparent binding affinity to Trx-His-tagged HIV integrase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.47 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3287916 | — | — | 1 | 7.77 |
| CHEMBL3287920 | — | — | 1 | 7.62 |
| CHEMBL3287922 | — | — | 1 | 7.58 |
| CHEMBL3287915 | — | — | 1 | 7.57 |
| CHEMBL3287923 | — | — | 1 | 7.55 |
| CHEMBL3287913 | — | — | 1 | 7.51 |
| CHEMBL3287921 | — | — | 1 | 7.46 |
| CHEMBL3287912 | — | — | 1 | 7.40 |
| CHEMBL3287924 | — | — | 1 | 7.40 |
| CHEMBL3287925 | — | — | 1 | 7.30 |
| CHEMBL3287918 | — | — | 1 | 7.28 |
| CHEMBL3287917 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3287916 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL3287920 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL3287922 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL3287915 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL3287923 | — | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL3287913 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL3287921 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL3287912 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL3287924 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL3287925 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL3287918 | — | Kd | = | 52.0 | nM | 7.28 |
| CHEMBL3287917 | — | Kd | = | 59.0 | nM | 7.23 |