Assay Detail
Binding
CHEMBL3299201
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Inhibition of JAK2 (unknown origin)
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.04 | 8.18 |
| Ki | 1 | 7.89 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.18 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 8.06 |
| CHEMBL3039513 | DECERNOTINIB | 2.0 | 2 | 7.89 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.11 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3039513 | DECERNOTINIB | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 77.4 | nM | 7.11 |
| CHEMBL3039513 | DECERNOTINIB | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 2400.0 | nM | 5.62 |