Assay Detail
Binding
CHEMBL3299298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1A (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.33 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409450 | 6BIO | — | 1 | 7.28 |
| CHEMBL3297832 | — | — | 1 | 7.12 |
| CHEMBL452220 | ATOLAPHYLLIDINE | — | 1 | 5.66 |
| CHEMBL3297831 | — | — | 1 | 5.24 |
| CHEMBL3297830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409450 | 6BIO | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3297832 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL452220 | ATOLAPHYLLIDINE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3297831 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3297830 | — | IC50 | > | 10000.0 | nM | - |