Assay Detail
Functional
CHEMBL3299928
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Antiproliferative activity against human HeLa cells after 24 and 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.99 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.54 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.47 |
| CHEMBL3298795 | — | — | 1 | 5.06 |
| CHEMBL2386825 | — | — | 1 | 4.65 |
| CHEMBL3298801 | — | — | 1 | 4.63 |
| CHEMBL3298800 | — | — | 1 | 4.54 |
| CHEMBL3298796 | — | — | 1 | 4.46 |
| CHEMBL3298803 | — | — | 1 | 4.39 |
| CHEMBL3298797 | — | — | 1 | 4.13 |
| CHEMBL3298798 | — | — | 1 | - |
| CHEMBL3298799 | — | — | 1 | - |
| CHEMBL3298802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3298795 | — | IC50 | = | 8710.0 | nM | 5.06 |
| CHEMBL2386825 | — | IC50 | = | 22480.0 | nM | 4.65 |
| CHEMBL3298801 | — | IC50 | = | 23620.0 | nM | 4.63 |
| CHEMBL3298800 | — | IC50 | = | 28850.0 | nM | 4.54 |
| CHEMBL3298796 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3298803 | — | IC50 | = | 40330.0 | nM | 4.39 |
| CHEMBL3298797 | — | IC50 | = | 74220.0 | nM | 4.13 |
| CHEMBL3298798 | — | IC50 | = | 116230.0 | nM | - |
| CHEMBL3298799 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL3298802 | — | IC50 | = | 286510.0 | nM | - |