Assay Detail
Functional
CHEMBL3299992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells expressing beta3-tubulin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.80 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.00 |
| CHEMBL3297898 | — | — | 1 | 7.57 |
| CHEMBL3298000 | — | — | 1 | 7.35 |
| CHEMBL3297899 | — | — | 1 | 6.69 |
| CHEMBL3297900 | — | — | 1 | 5.82 |
| CHEMBL3297999 | — | — | 1 | 5.39 |
| CHEMBL3297998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3297898 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL3298000 | — | IC50 | = | 44.7 | nM | 7.35 |
| CHEMBL3297899 | — | IC50 | = | 205.6 | nM | 6.69 |
| CHEMBL3297900 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3297999 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL3297998 | — | IC50 | > | 10000.0 | nM | - |