Assay Detail
Functional
CHEMBL3299999
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Cytotoxicity against human triple negative MDA-MB-468 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.45 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 8.21 |
| CHEMBL3298000 | — | — | 1 | 8.15 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.16 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.08 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3298000 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 69.1 | nM | 7.16 |
| CHEMBL554 | LAPATINIB | IC50 | = | 83.2 | nM | 7.08 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 235.2 | nM | 6.63 |